The role of glycogen synthase kinase 3 beta in neurodegenerative diseases

Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being and survival of elderly individuals worldwide. NDDs include Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), amyotrophic lateral sclerosis (ALS), so on. They are characterized by progressive loss or dysfunction neurons in central peripheral nervous system share several cellular molecular mechanisms, including protein aggregation, mitochondrial dysfunction, gene mutations, chronic neuroinflammation. Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase that believed play pivotal role pathogenesis NDDs. Here we summarize structure physiological functions GSK3β explore its involvement We also discussed potential as therapeutic target.